Algae cells that cheat are more likely to die of environmental stress

By James Dinneen

Algae cells that cheat are more vulnerable to stress. This trade-off could help explain the emergence of multicellular organisms, and what keeps cells in algae and cells in our bodies cooperating with one another. 

Whether among cells or in societies, there are always opportunities for individuals to cheat, reaping the benefits of a group without paying the costs of cooperation.

To shed light on the forces that keep cheaters in check, Aurora Nedelcu at the University of New Brunswick, Canada, and her colleagues turned to multicellular green algae Volvox carteri. V. carteri has two types of cells: reproductive cells that replicate and body cells that don’t. These normally work together. But, when a particular gene called regA is manipulated, the body cells cheat and start reproducing themselves.

Because body cells outnumber reproductive cells, they give rise to far more cells, each of which are capable of giving rise to more cheaters. Cheater mutants would seem to have an evolutionary advantage, yet cells in V. carteri ultimately cooperate.

Nedelcu and her team exposed regular and cheater mutant V. carteri to harsh conditions of light, darkness and heat. Half of the regular algae ended up with dead cells, whereas all of the cheater mutants had dead cells.

This suggests that cheater mutants are more vulnerable to environmental conditions, says Nedelcu. In V. carteri at least, it could be that the cost of cheating is steep enough to favour cooperation.

Benjamin Kerr at the University of Washington in Seattle, who wasn’t involved with the study, calls it a “fail-safe mechanism” that keeps cheaters in line. He says studies like this can reveal relationships between the collective and private good, adding to explanations for why cheaters don’t always win.

The same type of trade-off could also halt other kinds of cheaters. All single-celled organisms have genes that impose a balance between reproduction and survival. Many of these genes, like regA, persist in the lineages of multicellular organisms, including plants and animals.

Not only might these genes help keep multicellular organisms healthy, says Nedelcu, they also might have played an important role in the evolution of multicellularity hundreds of millions of years ago.

Journal reference: Biology Letters, DOI: 10.1098/rsbl.2022.0059